Myocardial Architecture, Mechanics, and Fibrosis in Congenital Heart Disease

Myocardial Architecture, Mechanics, and Fibrosis in Congenital Heart Disease

Congenital heart disease (CHD) is the most common category of birth defect, affecting 1% of the population and requiring cardiovascular surgery in the first months of life in many patients. Due to advances in congenital cardiovascular surgery and patient management, most children with CHD now survive into adulthood. However, residual and postoperative defects are common resulting in abnormal he...

Myocardial fibrosis in congenital and pediatric heart disease

Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying cause of fibrotic heart disease. There are four different types of cardiac fibro...

Congenital Heart Disease and Pregnancy

  ضایعات مادرزادی قلب خط مشی های گوناگونی از قبیل مراقبت دقیق بیماران باردار تا پیشگیری از بارداری و یا خاتمه آن را در زنان سن باروری ایجاب می کند. با پیشرفت روشهای درمان جراحی و دارویی در تصحیح و یا بر طرف کردن علایم بیماری مادرزادی، اکنون بسیاری از زنان مبتلا به مرحله باروری رسیده و باردار می شوند. اداره موفقیت آمیز این زنان در طی بارداری و بلافاصله بعد از زایمان به همکاری نزدیک بین متخصصین ...

Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease.

BACKGROUND the etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI. METHODS AND RESULTS patients with ACHD (n=50) were studied with cardiac MRI to quantify systemic ventricular volume and function and diffuse fibrosis. The fibrosis index for a single midventricular ...

Editorial: Ventricular Mechanics in Congenital Heart Disease